NCC recently received supplemental funding to pursue various projects related to the implementation of the Affordable Care Act (ACA). These projects will collect data regarding the cost to care for individuals with heritable conditions using two model conditions (Sickle Cell and PKU) and a state-by-state analysis of coverage under the ACA for the two model conditions. These two evidentiary-building projects will then assist the NCC/RCs as they work to education and inform Title V directors, State Public Health officials, state governors, the Association of State and Territorial Health Officials (ASTHO) and others. The final project will allow for active engagement and partnerships between the Regional Collaboratives (RCs) and Accountable Care Organizations (ACOs) and other local partners (including patient centered medical homes, state and local chapters of medical professional organizations, etc.). In particular, the RCs will work to define and standardize the genetic component of an ACO, and standardizing what defines genetics professionals/program’s accountability as part of the ACO. Genetics is a critical aspect of healthcare and its inclusion at the nascent stage in the ACA implementation will be an important collaboration with ACOs and other stakeholders.